William L Murphy
Assistant Professor

Contact Information

3152 Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706
Tel: 608/262-2224
Fax: 608/265-9239
E-mail: wlmurphy@wisc.edu

Program Affiliations

Courses

  • BME 301: Biomedical Engineering Design
  • BME 520: Stem Cell Bioengineering

Education

  • Postdoctoral Fellow 2002-2004, University of Chicago
  • PhD 2002, University of Michigan-Ann Arbor
  • MS 2000, University of Michigan-Ann Arbor
  • BS 1998, Illinois Wesleyan University

Fields of Interest

  • Creation of novel materials using bioinspired approaches
  • Using biomaterials to define the stem cell microenvironment
  • Development of biomaterials for tissue regeneration (tissue engineering)
  • Novel approaches to drug delivery and gene therapy

Publications

  • W.L. Murphy and G.C. Spalding. Range of interactions: An experiment in atomic and magnetic force microscopy. Am. J. Phys., 1999, 67, 905-909.
  • W.L. Murphy and D.J. Mooney. Controlled delivery of inductive proteins, plasmid DNA, and cells from tissue engineering matrices. J. Periodontal Res., 1999, 34, 413-419.
  • W.L. Murphy and P.B. Messersmith. Compartmental control of mineral formation: adaptation of a biomineralization strategy for biomedical use. Polyhedron., 2000, 19, 357-363.
  • W.L. Murphy, D.H. Kohn and D.J. Mooney. Growth of bone-like mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. J.Biomed. Mater. Res., 2000, 50, 50-58.
  • W.L. Murphy, M.C. Peters, D.H. Kohn and D.J. Mooney. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials, 2000, 24, 2521-2527.
  • W.L. Murphy and D.J. Mooney. Molecular-scale biomimicry. Nature Biotech., 2002, 20, 30.
  • W.L. Murphy, R.G. Dennis, J.L. Kileny and D.J. Mooney. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng., 2002, 8, 43-52.
  • W.L. Murphy and D.J. Mooney. Bioinspired synthesis of crystalline carbonated apatite on biodegradable polymer substrata. J.Am. Chem. Soc., 2002, 124, 1910-1917.
  • T.P. Richardson, W.L. Murphy, and D.J. Mooney. Selective adipose tissue ablation by localized, sustained drug delivery. Plast. Reconstruct. Surg., 2003, 112, 162-170.
  • W.L. Murphy C.A. Simmons, D. Kaigler and D.J. Mooney. Engineering bone regeneration via biomineral presentation and induced angiogenesis. J. Dent. Res., 2004, 83, 204-210.
  • W.L. Murphy, K.O. Mercurius and M. Mrksich. Active site-directed immobilization of a protein domain to mediate cell adhesion. Langmuir, 2004, 20, 1026-1030.
  • W.L. Murphy, S. Hsiong, T.P. Richardson, C.A. Simmons and D.J. Mooney. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials, 2005, 26:303-310.
  • W.L. Murphy, W.S. Dillmore, J. Modica, M. Mrksich. Dynamic Hydrogels: Translating a Protein Conformational Change into Macroscopic Motion. Angewandte Chemie Int. Ed., 2007;46:3066-3069.
  • Jason L. Wyman, Seda Kizilel, Ryan Skarbek, Xiangyang Zhao, Matthew Connors, William S. Dillmore, William L. Murphy, Milan Mrksich*, Sidney R. Nagel, Marc R. Garfinkel. Immunoisolating Pancreatic Islets by Encapsulation with Selective Withdrawal. Small, 2007, 3:683-690.
  • Z. Sui, W.J. King, W.L. Murphy. Dynamic materials based on a protein conformational change. Advanced Materials, 2007;19:3377-3380.
  • G. Hudalla, T.S. Eng, W.L. Murphy. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks, Biomacromolecules, 2008, 9: 842-849.
  • Z. Sui, W.J. King, W.L. Murphy. Protein-based hydrogels with tunable dynamic responses, Advanced Functional Materials, 2008, June 10. [epub ahead of print]
  • L. Jongpaiboonkit, W.J. King, G.E. Lyons, A. Paguirigan, J. Warrick, D.J. Beebe, W.L. Murphy, Adaptable hydrogel array format for 3-dimensional cell culture, Biomaterials, 2008, 29:3346-56.
  • S. Choi, W.L. Murphy. Multifunctional mixed SAMs that promote both cell adhesion and non-covalent DNA immobilization, Langmuir, 2008, May 29. [Epub ahead of print].
  • L. Jongpaiboonkit, W.J. King, W.L. Murphy. Screening for 3-D environments that support human mesenchymal stem cell viability using hydrogel arrays, Tissue Engineering, In Press, 2008.
  • B.J. Peret, W.L. Murphy. Controllable Soluble Protein Concentration Gradients in Hydrogel Networks, Advanced Functional Materials, In Press, 2008.

Selected Awards, Honors and Societies

  • 2003 NIH National Research Service Award
  • 2005 IADR/AADR William J. Gies Award
  • 2008 NSF CAREER award
  • Member: American Chemical Society, Society for Biomaterials, Biomedical Engineering Society

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